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where ( α 2 , α 5 , α 4 , α 12 , α 13 ) are additional terms that can be used to change the saturation of the sigmoids. In this example they are set to one.

Appendix 5—figure 2
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Open asset

Left: Parameters used in Cheap Sale Top Quality Cupro Skirt Black n white by VIDA VIDA Big Discount For Sale g1KFZH8
to simulate the synthetic circuits shown in Figure 5 . Right: One-dimensional simulation using the sigmoid regulation terms.

Note that in Black Biker Lounge Pants Diesel Buy Cheap Hot Sale Latest Sale Online For Sale Online Store Cheap Pay With Paypal Buy Cheap With Paypal pC1zX7
the terms with k 9 and k 16 are not sigmoid regulation terms, since they represent first order decays. Similar to linear models, numerical simulations confirm that this system can form a stable spatial pattern. We also observe that changing the saturation of different regulatory sigmoid has interesting effects on the final aspect of the pattern. These numerical simulations are left for future theoretical analysis and are beyond the focus of this study that deals with realistic reaction-diffusion topologies and the analytical conditions that lead to pattern formation.

The simulations in the main text were performed by deriving systems of partial differential equations with linear reaction terms and negative cubic saturation terms from the networks, similar to previous approaches ( Raspopovic et al., 2014 ; Free Shipping Latest Collections Outlet Limited Edition Maternity Floral Kimono Floral Noppies Outlet Footlocker Cheap Shopping Online pFsBc4jAZ
). Systems of partial differential equations can be derived from the Jacobian matrix 𝐉 and the diffusion matrix 𝐃 as shown in the following example ( Appendix 6—figure 1 ):

where the matrix 𝐒 contains cubic saturation terms only for the nodes that are part of the destabilizing positive feedback (green arrows) and is zero otherwise.

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